Cylera vs Asimily:
2026 Comparison

Introduction

Both Cylera and Asimily eliminate blind spots for IoMT by identifying connected hardware without requiring endpoint software agents. They profile equipment by manufacturer, model, and operating system, calculate risk indices, and generate microsegmentation policies for Network Access Control (NAC) systems to enforce.

Where they differ is depth of execution. Cylera, founded in 2017 in New York, provides a healthcare-tailored IoT security engine combining passive monitoring, contextual risk scoring, and policy generation for third-party enforcement (Cylera, accessed November 3, 2026). Asimily expands this foundation across IoT, OT, IoMT, and IT environments. It actively validates whether vulnerabilities are exploitable in a specific network context using a vulnerability-by-vulnerability ATT&CK Analysis from Asimily Labs, and delivers proactive remediation through risk-centric prioritization, automated IoT Patching, and configuration change tracking.

Explore the detailed comparisons below, ordered by security program maturity: visibility, vulnerability management, threat response, and active risk mitigation.

1. Inventory and Visibility

Both platforms build inventory without endpoint agents. Asimily expands coverage through deep packet inspection, AI and ML classification against a library of well over 10,000,000 observed devices and profiles, active querying, flow data, and correlation with over 150 different sources, such as Active Directory, CMDB, NACs, DHCP, vulnerability scanners, EDRs, and Mobile Device Managers. Active methods suit only devices that tolerate the traffic, so Asimily pairs them with passive collection. Asimily also discovers what runs on assets, including services, applications, middleware, and AI agents, helping to create a unified, normalized inventory.

Cylera says its agentless approach “does not rely on agents, network scanning of devices, or overdue manufacturer updates.” It captures make, model, operating system, vendor, network services, and software bill of materials (SBOM) attributes.

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2. Exposure Management

Inventory feeds exposure, and both platforms score risk per device. Cylera aggregates vulnerability data from sources such as the NIST National Vulnerability Database (NVD) and IoT device manufacturer databases, scores risk from device type, vulnerability assessments, behavioral analysis, and usage, and provides “detailed, step-by-step remediation instructions customized for each identified vulnerability and risk” (Cylera, accessed November 3, 2026). Asimily ranks vulnerabilities by impact and likelihood, and its ATT&CK Analysis tests whether a vulnerability is exploitable on a specific device in its network context, so teams work from a shorter list of the riskiest devices. Asimily’s risk analysis also draws on Manufacturer Disclosure Statements for Medical Device Security (MDS2) and SBOMs, and Risk Simulator models how a fix would change a device’s risk score before anyone acts. Asimily offers three ways to reduce exposure: patching (automatically where possible), tailored remediation (alter the context or configuration to thwart exploitability), or microsegmentation (continually updated and refined).

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3. Threat and Response

Both platforms detect anomalous device behavior and send threat data to security operations tools. Cylera builds “device-specific behavioral baselines” to flag anomalies (Cylera, July 3, 2025), and its Smart Threat Prioritization applies machine learning to correlate device, indicator of compromise (IOC), and in-service data. Cylera sends newly identified threats and risks to Splunk, Microsoft Sentinel, IBM QRadar, and Google Chronicle (Cylera, accessed November 3, 2026). Asimily’s anomaly policies alert or quarantine devices through NACs and supported firewalls when a policy is violated, and its SIEM integrations send anomaly events to a central system (and thus alerting). For incident response, Asimily can record packets from a monitored device, on demand or when a policy is violated, so responders start with the traffic itself and not only an alert.

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4. Risk Mitigation

Segmentation is a priority for most teams and still unfinished for many: Cisco’s 2025 Segmentation Report found that 79% call it a priority and only 33% have fully implemented it (Cisco). In clinical networks the fear of blocking a device during patient care is often what stalls enforcement. Both platforms generate access control policies to block exploits and still allow function, relying on NACs or firewalls for enforcement, such as Cisco ISE (both for DACLs and security group tags). Cylera “automatically generates recommended segmentation policies based on device profiles and clinical context” (Cylera, accessed November 3, 2026), and its Segmentation Policy Generator provides rule generation, auto-enrollment of new IoT devices, and policy monitoring. Cylera passes that intelligence to Cisco ISE over pxGrid, where TrustSec security group tags apply it (Cylera, June 20, 2025), and lists Check Point, Forescout, HPE Aruba ClearPass, and Extreme among the tools it supplies with device profiles.

Neither platform enforces at the switch itself; both rely on the NAC or firewall. Asimily can also run segmentation as a continuously updated process based on exploitability, with simulation before enforcement and an additional Enforcement Plan. Enforcement Plan is Asimily’s name for the pre-deployment checklist, that gives users a glimpse of how enforcement will work rather than hiding the details from users. Asimily’s Segmentation Orchestration creates conflict-free policies from actual device behavior, ranks them by exploitability, simulates them against live traffic with Policy Simulation, previews the Enforcement Plan, and applies policy through existing NACs and supported firewalls. Continuous Segmentation then applies NAC and firewall policies automatically to new matching devices. Asimily also adds IoT Patching and password management for supported IoT device types.

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5. Governance, Risk, and Compliance

Healthcare security teams answer to auditors, clinical engineering, and finance at once. Asimily’s Configuration Control captures configuration snapshots of IoT, OT, and IoMT devices to establish a known good state, detects configuration drift, and keeps a change history for audits. Asimily ProSecure delivers strategic pre-procurement risk analysis and actionable safe configuration guidance for devices before purchase by aggregating insights across customer fleets. In addition, Asimily monitors open FDA, BfArM, and Health Canada recalls against the inventory, and utilization data, including imaging procedures for imaging devices, supports capital planning. Cylera lists “compliance audit-readiness” through “reports and data export of inventory, risks, threats, and event logs,” and collects “usage telemetry to enable optimization and cost savings” (Cylera, accessed November 3, 2026). Ask each vendor how device change records and recall actions reach auditors.

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6. Sample Integrations

Both platforms integrate across IT, security, and clinical engineering tools. Cylera lists 17 integrations, including Cisco ISE, HPE Aruba ClearPass, Forescout, Extreme, Check Point, ServiceNow, Nuvolo, eQuip, Rapid7 InsightVM, Illumio, and four SIEM tools; most send Cylera’s device intelligence to the partner, and a few import device location or vulnerability data (Cylera, accessed November 3, 2026). Asimily correlates network, identity, endpoint, clinical engineering, and service management data, plus scanner results, into one record per device, and can apply policy through supported NACs and firewalls. Asimily integration categories and sample products include:

• AI & LLM Providers: Google Gemini, Anthropic Claude, others
• CMMS / CMDB: ServiceNow Service Graph, Nuvolo, i-doit, EQ2
• DHCP & DNS: Infoblox, BlueCat, EfficientIP
• Endpoint Detection and Response (EDR): CrowdStrike Falcon, Microsoft Defender, SentinelOne
• Firewalls & Network Infrastructure: FortiGate, Arista Agni, Juniper
• Identity and Access Management (IAM): Active Directory/LDAP, Azure SSO, SAML, Okta
• ITSM: ServiceNow ITSM, Jira, BMC Helix
• Location Services: Cisco Spaces, Aruba AirWave
• Mobile Device Management: Microsoft Intune, Jamf Pro, Jamf Cloud
• Network Access Control (NAC): Cisco ISE, Aruba ClearPass, FortiNAC, Forescout, Palo Alto Panorama
• Network Traffic Sources: NetFlow, sFlow, SNMP Walk
• Scanners and Vulnerability Management (VM): Tenable, Qualys, Rapid7
• SIEM: Elastic SIEM, CrowdStrike LogScale, Palo Alto Cortex XSOAR
• Threat Intelligence: Cisco XDR, CrowdStrike Falcon X

This is not a complete list. Integrations are added regularly and there are over 150 at this time.

7. Deployment Considerations

Both platforms avoid endpoint agents. Cylera’s datasheet describes “passive and agentless deployment” (Cylera, accessed November 3, 2026), and its Network Traffic Emulation creates virtual stand-ins for real IoT devices during active scans and probing. A customer-written Cisco Community guide describes a Cylera appliance at each site that collects traffic from a switch SPAN port and forwards it to Cylera’s cloud application (Cisco Community); Cylera’s own pages do not state its deployment options. Asimily is delivered as a cloud-based software as a service (SaaS) with on-premises deployment available, and collects data through Asimily Edge software on a dedicated appliance, a virtual machine, or switches that support Cisco application hosting.

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Worked Example: Segmenting a Group of Infusion Pumps

This example is illustrative, not a customer story. Observe: Asimily’s passive analysis shows infusion pumps on one VLAN talking to a drug library server and a time server, and to nothing else. Profile: Asimily classifies the pumps by make, model, and firmware, pulls the manufacturer’s MDS2 data, and ATT&CK Analysis shows which of their exposures an attacker could actually use, so the group ranks high. Propose: Segmentation Orchestration drafts a policy that allows only the observed flows. Simulate: Policy Simulation runs the draft against live traffic over a period the team chooses and lists any port or service that would be blocked, before anything changes on a clinical network. Enforce: the Enforcement Plan shows the steps for the team’s existing NAC, such as a downloadable ACL (DACL) on Cisco ISE or Aruba ClearPass, or for a supported firewall.

How to Test Both in a Proof of Value

Asimily’s stated expectation is value within 48 hours and most devices identified within 14 days. Run the same six checks on Cylera and on Asimily, on one site of your own network:

1. List the devices each platform finds on a sample clinical VLAN, including IoT, OT, and IT devices beyond medical equipment.
2. Ask which discovered vulnerabilities are exploitable in your environment, and why.
3. Take one proposed segmentation policy and record what it would block against observed traffic before it is enforced.
4. Confirm which enforcement point applies the policy, and how a change is rolled back.
5. Check what each platform does for a device that can be patched and for one that cannot.
6. Ask about recall tracking, configuration change history, data export, deployment model, and renewal terms.

When Cylera Fits Better

Cylera is a close fit for a hospital-only security program that wants a specialist vendor and already runs the network tools Cylera feeds. These cases favor Cylera:

• Healthcare-only focus. Cylera describes itself as trusted by healthcare networks and hospitals globally, and builds segmentation recommendations on “clinical context” (Cylera, accessed November 3, 2026).
• No probing of live devices. Cylera’s Network Traffic Emulation creates virtual stand-ins for IoT devices during active scans and probing (Cylera, accessed November 3, 2026), which suits teams that will not allow any query to reach a medical device.
• Existing Cisco ISE and TrustSec programs. Cisco’s Security Technical Alliance Partners pages list Cylera, which “integrates with Cisco ISE over pxGrid to bring medical IoT visibility into ISE” (Cisco, accessed November 3, 2026).
• Broad SIEM coverage. Cylera lists integrations with Splunk, Microsoft Sentinel, IBM QRadar, and Google Chronicle.
• UK and NHS presence. Cylera operates regional offices in the US and the UK (Cylera) and has announced contracts with NHS trusts.

The Bottom Line

Cylera: Cylera is a healthcare-focused IoT security platform that discovers and profiles devices passively and without agents, scores risk, detects anomalies, and generates segmentation policy that partner NACs such as Cisco ISE enforce. It suits hospital teams that want a specialist vendor and already run Cisco ISE or one of its other listed integrations.

Asimily: Asimily covers any connected asset: it builds the inventory first across IoT, OT, IoMT, and IT assets and the software running on them, then analyzes exploitability with a MITRE-based ATT&CK Analysis, then creates, simulates, and continuously maintains segmentation policy that existing NACs and supported firewalls enforce. Apart from discovery and segmentation, Asimily adds IoT Patching, Configuration Control, packet capture, recall monitoring, and Asimily ProSecure pre-procurement risk data with fleet-wide safest configuration recommendations. Like Cylera, it does not enforce at the switch, so it works through the NAC or firewall a team already runs.

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